Description
What is TB-500?
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4, a naturally occurring 43-amino-acid actin-sequestering protein, centered on the acetylated LKKTETQ sequence. Supplied as a lyophilized powder, it serves as a tractable research analog of full-length Thymosin Beta-4 for studying actin dynamics, cell migration, and vascular processes.
How TB-500 works (research context)
In-vitro research focuses on the LKKTET motif binding monomeric G-actin, maintaining a sequestered actin pool available for rapid polymerization during cell migration. By modulating actin dynamics the fragment is studied for facilitating movement of keratinocytes, endothelial cells, and myofibroblasts in wound-healing assays, and for contributions to angiogenesis.
Research applications
- In-vitro study of G-actin sequestration and cytoskeletal dynamics
- Cell-migration assays with keratinocytes, endothelial cells, and myofibroblasts
- Pre-clinical models of angiogenesis and microvascular formation
- Comparative recovery studies alongside BPC-157
Key facts
- Synthetic fragment of the 43-amino-acid protein Thymosin Beta-4
- Active sequence Ac-LKKTETQ from the actin-binding region
- Available in 5mg and 10mg research strengths
- Commonly co-studied with BPC-157 in tissue-repair research
Product specifications
- Class: Synthetic actin-binding fragment of Thymosin Beta-4
- Also known as: Thymosin Beta-4 fragment; Ac-LKKTETQ
- Form: Lyophilized powder vial
- Purity: ≥ 99% (HPLC verified)
- Testing: Independent third-party HPLC + mass spectrometry
- Documentation: Certificate of analysis per batch
- Storage: Store lyophilized at -20C; reconstituted solution refrigerated at 2-8C and used promptly.
For laboratory research use only. Not for human or veterinary use, consumption, diagnostic, or therapeutic purposes.
Rafael Souza –
Fast, discreet, cold-chain intact. Mass spec confirmed the fragment. Will reorder the 10mg.
D. Acheampong (verified owner) –
Quality powder, clear labeling. Vial arrived a touch warm but the COA purity held on our re-test.
Dr. Naomi Frost (verified owner) –
Co-studied alongside BPC-157 for cytoskeletal work — both lots matched their certificates. Excellent batch control.
Dr. Caleb Ortiz (verified owner) –
TB-500 reconstituted clean and our G-actin binding assay behaved exactly as expected. 99.1% by HPLC on the certificate.
Freya Lindholm (verified owner) –
Consistent Ac-LKKTETQ material — keratinocyte migration assays were reproducible. Reliable supplier, good documentation.