Description
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide, oxidized form) is a classical pyridine-nucleotide coenzyme found in all living cells. It is fundamental to cellular bioenergetics, cycling between oxidized (NAD+) and reduced (NADH) states to shuttle electrons. Beyond redox chemistry it serves as a consumable substrate for key enzyme families, and its measured decline across model organisms makes it a focal point in cellular-aging research.
How NAD+ works (research context)
In laboratory systems NAD+ operates in two modes. As a redox coenzyme it accepts and donates electrons during glycolysis, the TCA cycle, and oxidative phosphorylation, interconverting with NADH. As a signaling substrate it is consumed by sirtuin deacylases, poly-ADP-ribose polymerases involved in DNA repair, and CD38/CD157 enzymes. Research links these activities to chromatin remodeling, senescence, and mitochondrial function.
Research applications
- In-vitro studies of cellular redox balance and the NAD+/NADH ratio
- Research on sirtuin- and PARP-dependent signaling and DNA repair
- Pre-clinical models of NAD+ decline and cellular aging
- Mitochondrial bioenergetics and oxidative-metabolism investigation
Key facts
- Central redox coenzyme present in every living cell
- Cycles between oxidized (NAD+) and reduced (NADH) states
- Consumed as a substrate by sirtuins, PARPs, and CD38/CD157 enzymes
- Cellular levels decline measurably with age in model organisms
Product specifications
- Class: Pyridine-nucleotide coenzyme / redox cofactor
- Also known as: Nicotinamide Adenine Dinucleotide; Coenzyme I
- Form: Lyophilized powder vial
- Purity: ≥ 99% (HPLC verified)
- Testing: Independent third-party HPLC + mass spectrometry
- Documentation: Certificate of analysis per batch
- Storage: Store lyophilized at -20C, desiccated and protected from light; reconstitute and use promptly under refrigeration.
For laboratory research use only. Not for human or veterinary use, consumption, diagnostic, or therapeutic purposes.
Dr. Lukas Meyer (verified owner) –
PARP and CD38 substrate assays were reproducible with this lot. Reliable redox-cofactor reference.
Amara Singh (verified owner) –
Solid material and good documentation. It’s hygroscopic so handle fast, but it arrived properly desiccated and sealed.
Tessa B. –
Fast shipping, discreet packaging, clear lot tracking. Exactly what the lab needed for bioenergetics work.
Dr. Beatrix Lund (verified owner) –
NAD+ powder was high-purity by HPLC and our NAD+/NADH ratio assays ran clean. Dissolved fully with no residue.
Quentin Ross (verified owner) –
Used the 1000mg in sirtuin activity work — consistent substrate quality, low background. COA matched.