Description
What is HGH 191AA Somatropin?
HGH 191AA is recombinant human growth hormone (somatropin), a single-chain 191-amino-acid polypeptide identical in sequence to pituitary-derived human GH and produced via recombinant DNA expression. As the native ligand of the growth hormone receptor it is a primary reference molecule in endocrine research, measured in international units (IU) reflecting bioassay potency.
How HGH 191AA Somatropin works (research context)
Somatropin acts as the direct agonist of the transmembrane growth hormone receptor (GHR), a class-I cytokine receptor. Ligand binding induces receptor dimerization, activating the associated JAK2 tyrosine kinase. JAK2 phosphorylates STAT5, which translocates to the nucleus to modulate transcription, driving downstream expression of mediators including IGF-1 in model systems.
Research applications
- Reference ligand for in-vitro GH-receptor binding and JAK2/STAT5 studies
- Pre-clinical modeling of the GH/IGF-1 endocrine axis
- Comparative potency standard against GH secretagogues and analogs
- Cell-culture studies of GH-responsive gene transcription
Key facts
- Full-length 191-amino-acid recombinant human growth hormone
- Sequence-identical to native pituitary somatropin
- Signals via GHR dimerization and the JAK2/STAT5 pathway
- Potency expressed in international units (IU) per vial
Product specifications
- Class: Recombinant 191-amino-acid human growth hormone
- Also known as: Somatropin; Recombinant Human Growth Hormone; rhGH
- Form: Lyophilized powder vial
- Purity: ≥ 99% (HPLC verified)
- Testing: Independent third-party HPLC + mass spectrometry
- Documentation: Certificate of analysis per batch
- Storage: Store lyophilized at 2-8C; after reconstitution keep refrigerated and protect from agitation and light.
For laboratory research use only. Not for human or veterinary use, consumption, diagnostic, or therapeutic purposes.
Dr. Hannah Reyes (verified owner) –
IGF-1 induction downstream was exactly as expected. Consistent IU potency across two orders. Trustworthy source.
Dmitri V. (verified owner) –
Cold chain intact, vial sealed perfectly. COA confirmed sequence identity. Reordering the 24iu.
Lucia Romano (verified owner) –
JAK2/STAT5 activation in our GH-responsive line was robust and reproducible. Lyophilized disc was pristine and reconstituted gently with no aggregation.
P. Nakamura (verified owner) –
High-quality material and careful packaging. Pricier than the peptides but it’s full recombinant GH — worth it. Shipping prompt and cold.
Dr. Gregor Almeida (verified owner) –
Full-length 191AA somatropin — SDS-PAGE showed a single clean band and the COA potency in IU matched. Excellent reference GH for receptor work.