Description
What is Retatrutide?
Retatrutide (LY3437943) is a synthetic, fatty-acid-conjugated single peptide engineered to engage three incretin and metabolic receptors at once. It builds on the GLP-1/GIP pharmacology of earlier incretin mimetics by adding glucagon-receptor agonism. In a research-use-only context it serves as a reference compound for studying integrated incretin signaling, receptor cross-talk, and energy-expenditure pathways in cell-culture and pre-clinical models.
How Retatrutide works (research context)
In research models retatrutide acts as a balanced agonist at the GLP-1, GIP, and glucagon receptors, all class-B GPCRs signaling largely through cAMP. GLP-1/GIP activation is associated with insulinotropic and satiety-linked pathways, while glucagon agonism is studied for energy expenditure and hepatic lipid metabolism. A conjugated fatty-diacid moiety promotes albumin binding to extend its molecular half-life in laboratory systems.
Research applications
- In-vitro studies of GLP-1/GIP/glucagon receptor co-activation and signaling bias
- Pre-clinical models of energy expenditure and metabolic regulation
- Research into hepatic lipid metabolism and steatosis pathways
- Comparative incretin pharmacology versus dual and single agonists
Key facts
- Development code LY3437943; a single synthetic peptide, not a mixture
- Agonist at three receptors: GLP-1, GIP, and glucagon
- Conjugated to a fatty-diacid moiety for extended molecular half-life
- Supplied lyophilized; reconstitute with bacteriostatic water for in-vitro use
Product specifications
- Class: Triple GLP-1/GIP/glucagon receptor agonist
- Also known as: LY3437943
- Form: Lyophilized powder vial
- Purity: ≥ 99% (HPLC verified)
- Testing: Independent third-party HPLC + mass spectrometry
- Documentation: Certificate of analysis per batch
- Storage: Store lyophilized at -20C; reconstituted solution refrigerated at 2-8C, protected from light.
For laboratory research use only. Not for human or veterinary use, consumption, diagnostic, or therapeutic purposes.
Tomás R. –
COA emailed before the package arrived. Lyophilized powder dissolved with no cloudiness. Good traceability on the lot numbers.
J. Holloway (verified owner) –
Solid purity and tight vial fill. Shipping was a day slower than quoted but the cold pack was still cold on arrival. Already reordered.
Priya Nair (verified owner) –
Retatrutide lot matched the certificate exactly. cAMP readouts across the GLP-1, GIP and glucagon lines were clean and reproducible — great reference material for triple-agonist assays.
Dr. Lena Fischer (verified owner) –
Batch-to-batch consistency on the LY3437943 has been excellent over three orders — exactly what I need for comparative incretin pharmacology.
Dr. Marcus Vance (verified owner) –
Ordered the 10mg for receptor-binding work. COA listed 99.1% by HPLC and our in-house LC-MS confirmed the mass within tolerance. Cake was intact and reconstituted clear in bac water.