Description
What is Clomid?
Clomid (clomiphene citrate) is a triphenylethylene selective estrogen receptor modulator and a close structural relative of tamoxifen. It is supplied as a mixture of two geometric isomers — enclomiphene (trans, estrogen antagonist) and zuclomiphene (cis, weak agonist) — and is widely referenced in endocrine research as a model for hypothalamic ER antagonism and gonadotropin feedback.
How Clomid works (research context)
Clomiphene acts primarily at hypothalamic estrogen receptors as a competitive antagonist. By blocking estradiol binding at the hypothalamus, it disrupts negative feedback on GnRH secretion, leading to increased pulsatile GnRH release and consequent elevation of pituitary gonadotropins (LH and FSH) in model systems. The enclomiphene isomer accounts for most antagonist activity.
Research applications
- Reference SERM for hypothalamic-pituitary-gonadal axis feedback research
- In-vitro ER-alpha/beta binding and isomer-specific activity studies
- Pre-clinical models of gonadotropin regulation and pulsatility
- Comparative SERM pharmacology alongside tamoxifen
Key facts
- Triphenylethylene SERM; mixture of enclomiphene (trans) and zuclomiphene (cis)
- Hypothalamic ER antagonist disrupting negative feedback on GnRH
- Stimulates endogenous gonadotropin (LH/FSH) release in models
- Supplied as 50mg oral tablets (100 count) for reference research
Product specifications
- Class: Selective estrogen receptor modulator (SERM), small molecule
- Also known as: Clomiphene citrate; SERM
- Form: Oral tablets
- Verification: Identity and quality checked per batch
- Documentation: Certificate of analysis per batch
- Storage: Store tablets at controlled room temperature in a dry, light-protected container.
For laboratory research use only. Not for human or veterinary use, consumption, diagnostic, or therapeutic purposes.
Raj P. (verified owner) –
Documentation is thorough and the support team answered technical questions quickly.
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Great purity and fast shipping. Labeling and batch numbers were clear and fully traceable.
Liam W. (verified owner) –
Fast turnaround and the COA was emailed before the package even arrived. Excellent traceability.
Marcus T. (verified owner) –
COA matched the label exactly — 99.2% purity by HPLC. The only source I trust for research-grade material.
Jordan P. (verified owner) –
Discreet packaging, cold-chain intact, arrived in two days. Support actually understands the science.