Nolvadex

Description

What is Nolvadex?

Nolvadex (tamoxifen citrate) is a triphenylethylene-derived selective estrogen receptor modulator (SERM) and a foundational reference compound in nuclear-receptor pharmacology. It acts as a competitive antagonist at the estrogen receptor in certain tissues while displaying agonist activity in others. Supplied as 20mg oral tablets (100 count) for reference and pre-clinical laboratory study.

How Nolvadex works (research context)

Tamoxifen is a prodrug; its active metabolite 4-hydroxytamoxifen (endoxifen) competes with estradiol for binding to estrogen receptors alpha and beta. In ER-positive research models, tamoxifen-bound ER dimers recruit corepressors rather than coactivators, suppressing ERE-mediated transcription of estrogen-responsive genes. This tissue-selective antagonist/agonist profile makes it a key reference for SERM pharmacology.

Research applications

• Reference SERM for in-vitro estrogen-receptor binding and transcriptional assays
• Research into tissue-selective ER modulation and corepressor recruitment
• Pre-clinical models of estrogen-dependent signaling pathways
• Comparative pharmacology versus aromatase inhibitors and other SERMs

Key facts

• Triphenylethylene SERM; first approved in the 1970s
• Prodrug metabolized to active endoxifen (4-hydroxytamoxifen)
• Competitive ER antagonist with tissue-selective activity
• Supplied as 20mg oral tablets (100 count) for reference research

Product specifications

• Class: Selective estrogen receptor modulator (SERM), small molecule
• Also known as: Tamoxifen citrate; SERM
• Form: Oral tablets
• Verification: Identity and quality checked per batch
• Documentation: Certificate of analysis per batch
• Storage: Store tablets at controlled room temperature in a dry, light-protected container.

For laboratory research use only. Not for human or veterinary use, consumption, diagnostic, or therapeutic purposes.